New, Simple and Sensitive Voltammetric Procedure for Determination of Paracetamol in Pharmaceutical Formulations

A new, simple and sensitive adsorptive stripping voltammetric procedure for determination of paracetamol at a lead film glassy carbon electrode modified with Nafion film (Nafion/PbF/GCE) in pharmaceutical formulations was described. Deposition of lead film on a glassy carbon electrode from 0.1 mol L-1 HNO3 at the potential of -1.4 V was performed. The Nafion film coating was carried out by applying a 0.5 μL drop of 1% (w/v) Nafion solution onto the lead film electrode surface. At the potential of -1.45 V for 60 s paracetamol was accumulated by adsorption on the electrode from 0.1 mol L-1 H2SO4. Experimental results indicate excellent linear correlation between the paracetamol peak current and its concentration in the range from 5 × 10-7 to 1 × 10-2 mol L-1 with accumulation time equal to 60 s. The detection and quantification limits were 1.72 × 10-7 mol L-1 and 5.97 × 10-7 mol L-1, respectively. The elaborated procedure was successfully applied for determination of paracetamol in commercially available pharmaceutical formulations.